Best Python Development Companies in USA for 2025

TL;DR
In 2025, Python is the undisputed leader in AI, machine learning, and complex backend development. Choosing the right development partner is crucial for building scalable, intelligent applications. This article ranks the Best Python Development Companies in the USA. We have evaluated these firms based on their technical expertise in frameworks like Django and Flask, their proven experience in AI/ML, and their ability to deliver high-performance Python Application Development. This guide is your essential resource for finding the ideal partner for your next data-driven, scalable software project.

Introduction

When it comes to innovation, Python is the language behind it all. From AI-powered chatbots to predictive healthcare systems and large-scale data pipelines, Python continues to shape the technology landscape in 2025.

Its simple syntax, powerful frameworks, and unmatched support for data science and machine learning make it the first choice for developers and enterprises alike.

But here’s the thing: writing code is easy; building a secure, scalable, and intelligent system is not.

.That’s why businesses turn to the Best Python Development Companies.
These are not just coders; they are expert engineers who understand architecture, data structures, APIs, and the full Python ecosystem.

This blog highlights the top companies in the U.S. that have mastered the art (and science) of Python Application Development so that you can choose your ideal technology partner with confidence.

Top 10 Python Development Companies in USA for 2025

Here is our curated list of the leading Python development providers for 2025.

1. Wildnet Edge

• Headquarters: New York, Seattle, Austin, & more
• Services: Custom AI & Machine Learning Solutions, Enterprise Python Application Development, Data Science & Analytics, Big Data Engineering, Python Web Development, and robust backend API development.
• Industries Served: Healthcare, Finance, Retail & E-commerce, Logistics, Education, Real Estate, & Manufacturing.
• Key Highlights:
  • Over 19 years of industry experience (Founded 2005).
  • Enterprise-scale team of 350+ certified engineers.
  • Proven track record with 8,000+ projects delivered for 4,100+ clients.
  • Deep expertise in Django, Flask, TensorFlow, PyTorch, and Scikit-learn.
  • Specializes in building secure, scalable, and intelligent data-driven applications.

As a premier technology partner, their team of senior Python architects excels at leveraging the language for its greatest strengths: AI, machine learning, and large-scale backend systems. They are masters of the full Python stack, delivering secure, scalable, and intelligent solutions.

The company’s approach is that of a full-lifecycle engineering partner. They built mission-critical systems, from complex Python Web Development projects using Django to advanced AI models using TensorFlow and PyTorch. Their team manages the entire process, from data pipeline engineering and model training to API development and cloud deployment on AWS and Azure.

What truly sets Wildnet Edge apart is its enterprise-grade scale and reliability. With over 19 years in business, a CMMI Level 3-appraised process, and a large team of over 350 engineers, they have the proven experience to handle the most demanding projects. They are a top partner for businesses in high-compliance industries, where security, performance, and scalability are non-negotiable.

Projects Built (Highlights):

• AI Fraud Detection System: Built a Python-based platform for a FinTech company using PyTorch to detect fraudulent transactions in real-time, cutting fraud rates by 75%.
• Healthcare Analytics Platform: Designed a HIPAA-compliant data solution using Django and Pandas to analyze millions of patient records and predict health outcomes.
• Global E-commerce Backend: Developed a Flask-based microservices system managing millions of SKUs and real-time inventory tracking.

2. Caktus Group

• Headquarters: Durham, NC
• Services: Custom Django Web Development, API Development, Data Dashboards, Mobile App Development.
• Industries Served: Non-profit, Higher Education, Healthcare, Media.
• Key Highlights:
  • Founded in 2007.
  • Small, specialized team (10-49 employees).
  • Strong focus on “building apps that matter” for social good.
  • One of the premier Django-focused agencies in the US.

Caktus Group is a highly-respected boutique agency with a deep specialization in the Django framework. They are an ideal choice for non-profits, universities, and healthcare organizations that need a high-touch, mission-driven partner to build custom web applications, data visualization tools, and complex public-facing websites.

3. Saritasa

• Headquarters: Newport Beach, CA
• Services: Custom Software Development, Mobile App Development, IoT Solutions, Python Development.
• Industries Served: Logistics, Healthcare, FinTech, Real Estate.
• Key Highlights:
  • Founded in 2005.
  • Mid-sized team (50-249 employees).
  • Strong focus on full-stack development (including Python).
  • Extensive experience with complex integrations and IoT.

A full-stack software company with strong Python expertise. Saritasa combines IoT, mobile, and web development, making them ideal for businesses that need Python apps integrated with hardware or real-time systems.

4. Parthenon Software Group

• Headquarters: Vancouver, WA
• Services: Custom Software Development, Web Development, Mobile App Development.
• Industries Served: Manufacturing, Healthcare, Professional Services.
• Key Highlights:
  • Founded in 2006.
  • Small, agile team (10-49 employees).
  • Focuses on building custom, line-of-business applications.
  • Strong expertise in Python/Django and .NET.

Parthenon Software Group is a firm that excels at building custom line-of-business applications. They are a strong choice for manufacturing and service-based companies that need a tailored software solution to manage internal operations, and their small, expert team provides a highly collaborative experience.

5. Imaginary Landscape

• Headquarters: Evanston, IL
• Services: Django Web Development, Python Consulting, Website Support & Maintenance.
• Industries Served: Associations, Non-profit, Publishing, Higher Education.
• Key Highlights:
  • Founded in 1995.
  • Small, veteran team (10-49 employees).
  • One of the oldest and most experienced Django agencies.
  • Strong focus on long-term support and maintenance plans.

One of the oldest Django-focused agencies in the U.S. Founded in 1995, they are trusted for long-term support and maintenance of complex Python web platforms perfect for organizations that value stability.

6. Fusionbox

• Headquarters: Denver, CO
• Services: Custom Python & Django Development, Web Design, Security Audits.
• Industries Served: Healthcare, FinTech, E-commerce, Startups.
• Key Highlights:
  • Founded in 2001.
  • Small, senior-level team (10-49 employees).
  • Security-first development approach.
  • Strong focus on startups and HIPAA-compliant applications.

A boutique Python shop with a security-first approach. Fusionbox is known for building HIPAA-compliant systems for healthcare and FinTech startups ensuring privacy and compliance from day one.

7. Savas Labs

• Headquarters: Raleigh, NC
• Services: Web Application Development, UI/UX Design, Data Visualization, Digital Strategy.
• Industries Served: Higher Education, Healthcare, Non-profit, Media.
• Key Highlights:
  • Founded in 2015.
  • Small team (10-49 employees).
  • Strong focus on design, accessibility (WCAG), and user experience.
  • Expertise in both Python/Django and Drupal.

Savas Labs is a design-driven development agency. They are an ideal choice for organizations that need their web application to be not only functional but also beautiful, intuitive, and accessible to all users. Their expertise in data visualization makes them a great partner for building custom dashboards.

8. Plavno

• Headquarters: San Francisco, CA
• Services: Custom Software Development, AI & ML, Mobile App Development, Staff Augmentation.
• Industries Served: FinTech, E-commerce, Healthcare, Real Estate.
• Key Highlights:
  • Founded in 2007.
  • Mid-sized team (50-249 employees).
  • Focuses on AI-driven solutions and staff augmentation.
  • Delivers solutions for startups and enterprises.

Plavno is a full-service software firm that leverages Python’s strengths in AI and ML. They are one of the Best Python Development Companies for businesses that need to augment their team with AI experts or build a new product that has artificial intelligence at its core.

9. Go Wombat

• Headquarters: Wilmington, DE
• Services: Web & Mobile App Development, UI/UX Design, Python/Django Development.
• Industries Served: Healthcare, E-commerce, FinTech, Education.
• Key Highlights:
  • Founded in 2015.
  • Mid-sized team (50-249 employees).
  • Strong focus on startups and MVP development.
  • 5.0-star rating on Clutch.

Go Wombat is focused on helping startups and businesses build new digital products. They are a strong partner for building an MVP (Minimum Viable Product), combining agile Python Web Development with quality UI/UX design to get ideas to market quickly.

10. Closeloop Technologies

• Headquarters: Santa Clara, CA
• Services: Custom Software Development, Mobile Apps, AI Development, Cloud & DevOps.
• Industries Served: E-commerce, FinTech, Healthcare, Logistics.
• Key Highlights:
  • Founded in 2011.
  • Mid-sized team (50-249 employees).
  • Strong focus on end-to-end digital product development.
  • Certified AWS and Google Cloud Partner.

Closeloop Technologies is a full-service digital product consultancy. They are a reliable choice for businesses that need a single partner to handle the entire technology stack, from Python backend and AI models to the cloud infrastructure (AWS, GCP) that runs it all.

Comparative Matrix: Top 10 Python Development Companies

Company	Headquarters	Core Services	Industries Served	Founding Years
Wildnet Edge	New York, NY	Enterprise Python, AI/ML, Data Science	Healthcare, Finance, E-commerce	2005
Caktus Group	Durham, NC	Django Web Dev, Data Dashboards	Non-profit, Higher Ed, Healthcare	2007
Saritasa	Newport Beach, CA	Custom Software, IoT, Python	Logistics, Healthcare, FinTech	2005
Parthenon Software	Vancouver, WA	Custom Software, Django, .NET	Manufacturing, Healthcare, Services	2006
Imaginary Landscape	Evanston, IL	Django Dev, Python Consulting, Support	Associations, Non-profit, Publishing	1995
Fusionbox	Denver, CO	Python/Django Dev, Security Audits	Healthcare, FinTech, Startups	2001
Savas Labs	Raleigh, NC	Web Apps, UI/UX, Data Viz	Higher Ed, Healthcare, Non-profit	2015
Plavno	San Francisco, CA	AI/ML, Staff Augmentation, Python	FinTech, E-commerce, Healthcare	2007
Go Wombat	Wilmington, DE	Web & Mobile Apps, MVP, Django	Healthcare, E-commerce, FinTech	2015
Closeloop Technologies	Santa Clara, CA	Custom Software, AI, DevOps	E-commerce, FinTech, Healthcare	2011

How We Chose the Best Python Development Companies

We considered five key factors while selecting the top firms 

1. Python Expertise & Framework Mastery

Companies were evaluated on their command over Django, Flask, and modern Python tools for web and AI development.

2. Experience with AI/ML & Data

Top firms demonstrated proven experience in machine learning, data science, and automation the future of Python.

3. Project Scale & Success

We looked at enterprise projects, case studies, and measurable client outcomes across multiple industries.

4. Client Reviews & Reliability

Verified client feedback, 5-star ratings, and repeat business helped identify companies with long-term trust.

5. Cloud & DevOps Readiness

Since most Python systems today run in the cloud, expertise in AWS, Azure, or GCP was a key ranking factor.

Conclusion

In 2025, Python is the engine behind the world’s most innovative technologies. Choosing the right partner from the Best Python Development Companies is the most important decision you can make to ensure your project’s success. The firms on this list, including industry leaders like Wildnet Edge, provide the critical architectural and engineering expertise to build secure, scalable, and intelligent applications. By selecting a top-tier partner, you are not just hiring coders; you are investing in a robust foundation for your business’s future in the age of AI and data.

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